The Impact of Clinical and Histopathological Factors on Disease Progression and Survival in Thick Cutaneous Melanomas

Thick cutaneous melanomas (Breslow depth > 4 mm) are locally advanced tumors, generally associated with poor prognosis. Nevertheless, these tumors sometimes display unpredictable behavior. This study aims to analyze clinical and histopathological features that can influence the prognosis of thick melanomas. is a retrospective on 94 primary diagnosed between 2012 2018 were followed-up for at least five years assess disease progression survival. We evaluated age, gender, tumor location, histological subtype, Breslow depth, Clark level, resection margins, mitotic index, presence/absence ulceration, necrosis, regression, microsatellites, neurotropism, lymphovascular invasion, pattern tumor-infiltrating lymphocytes, their association By conducting univariate analysis, we found progression-free survival (PFS) was significantly female superficial spreading melanoma (SSM) perineural invasion. Overall (OS) SSM Through multivariate Cox proportional hazards only factors PFS while OS Certain such as invasion could explain differences in evolution. one first studies demonstrate an necrosis outcomes patients identifying high-risk patients, personalized therapy be provided improved